Anti-Ia antibody eluted from rejected human renal allografts
Additional evidence has been gathered that anti-Ia antibody may be an important component in graft presensitization as well as a useful correlate of rejection activity. Finding anti-Ia antibody positive for EAI in 8/9 eluates from rejected kidneys supports a pathogenetic role for these antibodies. The recent demonstration of Ia antigens on vascular endothelium, together with the evidence of severe vascular injury in our rejected grafts, provides additional corroboration for the hypothesis that anti-Ia antibodies are instrumental in producing the vascular lesions characteristic of humoral rejection. Thus, in addition to direct cell-mediated injury, anti-HLA antibodies of A, B and C locus specificity and anti-Ia antibodies may also act to further graft injury through pathways of complement-dependent lysis and cellular activation.