Further observations on the use of 5 hydroxytryptophan in a child with Lesch Nyhan syndrome Academic Article uri icon

Overview

MeSH Major

  • 5-Hydroxytryptophan
  • Carbidopa
  • Hydrazines
  • Lesch-Nyhan Syndrome

abstract

  • The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, and carbidopa, a peripheral aromatic amino acid decarboxylase inhibitor, were studied in a boy with the Lesch-Nyhan syndrome. No effects on the self-mutilating behaviors of this disorder were noted. However, sleep patterns were normalized, with a reduction in the proportionate amounts of wakefulness and an augmentation of active sleep. A sharp reduction in waking behavioral dyskinesias was also correlated to increased drug dosage.

publication date

  • December 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 308621

Additional Document Info

start page

  • 157

end page

  • 66

volume

  • 9

number

  • 2