Measurement of liver blood flow in the dog using krypton-85 clearance: A comparison with electromagnetic flowmeter measurements
Mitral Valve Insufficiency
Blood flow in the superficial liver tissue was measured by recording the clearance rate of the β emissions of 85Kr following its injection into the portal vein. The flow values calculated from monoexponential clearance curves were compared to portal venous blood flow simultaneously recorded with a calibrated electromagnetic flow probe in six dogs whose hepatic artery had been ligated. The liver: blood partition coefficient of 85Kr was measured in these dogs and was found to be 0.91. There was a close correlation (r = 0.95) between the blood flow values obtained from the two techniques over a wide range of flow values. This shows that measurement of liver blood flow in the surface layers of the liver using the 85Kr clearance method provides a true reflection of the blood flow in the liver tissue as a whole. © 1978.
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