Appearance of β-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation Academic Article uri icon


MeSH Major

  • Brain
  • Endorphins


  • beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable pain. This procedure involved the focal stimulation of a medial thalamic site adjacent to the wall of the third ventricle. Samples were collected before and during the analgesic stimulation. No beta-endorphin-like immunoreactivity could be detected prior to stimulation, suggesting that baseline levels are below 25 fmol/ml of cerebrospinal fluid. Electrical stimulation led to substantial increases (13- to 20-fold) in immunoreactive material in every subject. These results suggest that beta-endorphin-like material can be released into the ventricular system and may contribute to the pain blockade that results from periventricular stimulation.

publication date

  • December 1978



  • Academic Article



  • eng

PubMed Central ID

  • PMC336286

PubMed ID

  • 283422

Additional Document Info

start page

  • 5170

end page

  • 2


  • 75


  • 10