Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Endorphins
  • Enkephalins
  • Pain

abstract

  • Enkephalin-like activity has been measured in the ventricular cerebrospinal fluid of patients with intractable pain. Electrical stimulation of periventricular brain sites resulted in significant decrease in persistent pain in these subjects. This analgesia, which was blocked by naloxone in 80% of the cases, was accompanied by a significant rise in ventricular enkephalin-like activity, as measured by two different methods. The results present evidence of in vivo release of enkephalin-like material in humans and suggest that stimulation analgesia may be partially due to this release.

publication date

  • December 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 663668

Additional Document Info

start page

  • 463

end page

  • 5

volume

  • 201

number

  • 4354