Inhibition of viral reverse transcriptase and human sperm DNA polymerase by anti-sperm antibodies Academic Article uri icon

Overview

MeSH Major

  • DNA-Directed DNA Polymerase
  • Immunoglobulin G
  • RNA-Directed DNA Polymerase
  • Spermatozoa

abstract

  • The IgG fraction of serum from a rabbit immunized with detergent-prepared human sperm nuclei inhibited the DNA polymerase activities in human sperm and seminal fluid as well as the partially purified reverse transcriptase of the baboon endogenous type-C retrovirus (BEV). The analogous enzymes from lysates of oncogenic type-C viruses was unaffected. IgG from the serum of individual partners from infertile marriages similarly inhibited both purified BEV reverse transcriptase and human sperm DNA polymerase, but not a DNA polymerase isolated from human prostatic fluid. The data suggest that BEV reverse transcriptase and the human sperm DNA polymerase are antigenically related. Furthermore, the sperm appears to be auto-antigenic and the antibodies thus formed may be capable of interfering with reproductive success.

publication date

  • December 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1537572

PubMed ID

  • 82498

Additional Document Info

start page

  • 244

end page

  • 51

volume

  • 33

number

  • 2