Lipoprotein-apoprotein exchange in aqueous systems: Relevance to the occurrence of APOA-I and APOC proteins in a common particle Academic Article Article uri icon

Overview

MeSH Major

  • Obesity
  • Thinness
  • Weight Gain

abstract

  • Human plasma high density lipoproteins (HDL) were labeled in vitro with [125I]apoA-I. Chromatography of the [125I]HDL on Sephacryl S-200 revealed that a certain fraction of [125I]apoA-I readily dissociates from the intact particle over a wide range of HDL concentrations. The relatively constant value of the dissociated apoA-I concentration observed at various HDL concentrations suggests that a "critical monomer concentration" of apoA-I is in equilibrium with the parent lipoprotein. Addition of [131I]apoC proteins to HDL induces additional dissociation of oligomeric apoA-I with the concomitant incorporation of apoC into a new particle of about 460,000 daltons. © 1978 Academic Press, Inc.

publication date

  • November 14, 1978

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0006-291X(78)80057-6

PubMed ID

  • 217378

Additional Document Info

start page

  • 408

end page

  • 14

volume

  • 85

number

  • 1