The hepatic arterial and portal venous circulations of the liver studied with a krypton-85 clearance technique
Mitral Valve Insufficiency
Previous animal studies of liver blood flow (LBF) with the radioactive inert gas clearance technique have shown that the clearance rate of gas after its injection into the hepatic artery (HA) is slower than following injection into the portal vein (PV). Separation of HA and PV blood in the hepatic sinusoids has been suggested as an explanation. In the present study, alternate bolus injections of 85Kr were made into the PV and HA in two groups of dogs. In the first group, injection into the HA resulted in calculated LBF values 31% lower than those derived from PV injections. The second group was subjected to a dissection which isolated the liver from local recirculation of 85Kr from HA to PV via collateral vessels. In this group, calculated LBF values were identical after PV and HA injections. This finding supports the concept that the hepatic parenchyma is perfused by mixed HA and PV blood. © 1978.
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