Effect of glucocorticoids and ACTH on antipyrine clearance in children
Academic Article
Overview
MeSH Major
Adrenocorticotropic Hormone
Antipyrine
Glucocorticoids
abstract
Administration of dexamethasone and infusion of adrenocorticotropic hormone (ACTH) to children for periods up to 4 days did not alter the half-life, apparent volume of distribution, or metabolic clearance rate of antipyrine, a drug principally metabolized by the mixed-function oxidase system of the liver. We conclude that the short-term administration of glucocorticoids and ACTH with ensuing stimulation of endogenous glucocorticoid production is unlikely to produce clinically significant changes in the rate of drug metabolism.
