Effect of glucocorticoids and ACTH on antipyrine clearance in children Academic Article uri icon

Overview

MeSH Major

  • Adrenocorticotropic Hormone
  • Antipyrine
  • Glucocorticoids

abstract

  • Administration of dexamethasone and infusion of adrenocorticotropic hormone (ACTH) to children for periods up to 4 days did not alter the half-life, apparent volume of distribution, or metabolic clearance rate of antipyrine, a drug principally metabolized by the mixed-function oxidase system of the liver. We conclude that the short-term administration of glucocorticoids and ACTH with ensuing stimulation of endogenous glucocorticoid production is unlikely to produce clinically significant changes in the rate of drug metabolism.

publication date

  • June 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 206402

Additional Document Info

start page

  • 692

end page

  • 6

volume

  • 23

number

  • 6