Inhibition of human erythropoietic colony formation in culture by treatment with Ia antisera* Academic Article Article uri icon

Overview

MeSH Major

  • Circumcision, Male
  • Patient Acceptance of Health Care
  • Surgical Procedures, Operative

abstract

  • Incubation with Ia antiserum, followed by complement, markedly inhibited erythroid colonies arising from hematopoietic cells present in the nonadherent low density fractions of normal bone marrow. Both erythropoietin-dependent colonies and bursts were eliminated at dilutions of antiserum equivalent to, or greater than the dilutions required to abolish the granulocyte-macrophage colony formation. The inhibitory effect of the Ia antiserum was abolished by absorption with B but not T cells from lymphoid lines. Available evidence suggested that Ia determinants are expressed on the erythropoietin-sensitive progenitors of the erythroid series in precise analogy to their sequence of expression on the granulocyte lineage. In both lineages, as shown previously, the Ia determinants become undetectable during subsequent stages of differentiation.

publication date

  • August 1978

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1084/jem.148.2.613

PubMed ID

  • 702050

Additional Document Info

start page

  • 613

end page

  • 8

volume

  • 148

number

  • 2