Immune-complex-mediated glomerulonephritis and pulmonary hemorrhage simulating Goodpasture syndrome Academic Article Article uri icon

Overview

MeSH Major

  • Adolescent Medicine
  • Electronic Cigarettes

abstract

  • Two female children whose clinical presentations and renal light-microscopic findings were consistent with Goodpasture syndrome are described. Immunopathologic studies demonstrated granular deposition of immunoglobulins and complement, suggesting that the renal disease was mediated by circulating immune complexes and not by anti-glomerular basement membrane antibody. Anti-GBM antibody was absent in both patients. These patients represent the first report in children of idiopathic nephritis due to immune complexes with associated pulmonary hemorrhage. The findings raise some doubt as to the accuracy of previous reports of Goodpasture syndrome in children, and also demonstrate the diagnostic and therapeutic importance of evaluation the renal immunopathology in the child with nephritis and pulmonary hemorrhage.

publication date

  • January 1978

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0022-3476(78)80491-0

PubMed ID

  • 149843

Additional Document Info

start page

  • 181

end page

  • 4

volume

  • 93

number

  • 2