Cerebral Malaria: A Disseminated Vasculomyelinopathy Academic Article Article uri icon


MeSH Major

  • Breast Implants
  • Mammaplasty
  • Surgical Flaps


  • Neuropathologic examination of 19 fatal cases of cerebral malaria and a review of the literature showed that the epidemiologic, clinical, and pathologic features of this entity suggest consideration of cerebral malaria as a form of disseminated vasculomyelinopathy, a hyperegic reaction of the CNS to the antigenic challenge of Plasmodium falciparum infection. Experimental evidence also substantiates this view The initial event seems to be vasculopathy, with alteration of the endothelial permeability, followed by brain edema, perivascular infiltrates and ring hemorrhages, perivascular demyelination, and gliosis (malarial granuloma) in the late stages. This chain of events could be interrupted early in its course by corticosteroids. Parenteral dexamethasone should then be seriously considered at the first signs of involvement of the CNS during P falciparum malaria along with the standard forms of antimalarial therapy.

publication date

  • January 1978



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1001/archneur.1978.00500290017004

PubMed ID

  • 348169

Additional Document Info

start page

  • 271

end page

  • 5


  • 35


  • 5