Metabolic fate of the major cell surface protein of normal human fibroblasts Academic Article Article uri icon


MeSH Major

  • Braces
  • Exercise Therapy
  • Intervertebral Disc
  • Low Back Pain
  • Spinal Diseases


  • The major cell surface protein of a strain of human fetal lung fibroblasts is a 220,000 dalton glycoprotein termed fibronectin. Fibronectin is released from fibroblasts into the culture medium with a half-time of about 25 hours. The release occurs with an initial (0-3 hours) rapid phase followed by a second (3-48 hours) slower phase. Release of fibronectin occurs in a stoichiometric fashion. All of the fibronectin released from the cells is quantitatively recovered from the culture media as a similar sized soluble glycoprotein. Thus, release of fibronectin from normal human fibroblasts results from mechanisms other than extensive degradation of the protein. © 1977.

publication date

  • November 7, 1977



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(77)90053-5

PubMed ID

  • 921809

Additional Document Info

start page

  • 8

end page

  • 15


  • 79


  • 1