The coexistence of nodular and diffuse patterns in nodular non‐Hodgkin's lymphomas. Significance and clinicopathologic correlation Academic Article Article uri icon


MeSH Major

  • Hematopoietic Stem Cell Transplantation
  • Lung Diseases, Fungal
  • Respiratory Insufficiency


  • One hundred and twenty-six cases of nodular lymphoma have been classified cytologically by the criteria of Rappaport, and have been divided into three architectural groups, based on the degree of nodularity. Eighty-five percent of the patients have been followed for at least 5 years after initial therapy. Analysis of actuarial survival curves reveals that patients in the poorly differentiated lymphocytic and mixed histiocytic-lymphocytic categories with the three architectural patterns ("nodular only," "nodular with focal diffuse," and "nodular with diffuse") have similar long-term and disease-free survivals. Nevertheless, any degree of nodularity imparts a more favorable prognosis than diffuse lymphoma of coreresponding cell type. In the small number of patients with a nodular lye than in the other two histiocytic type, associated with diffuse areas, the prognosis is less favorable than in the other two histologic groups. Thus, a nodular lymphoma of so-called histiocytic type with diffuse areas may behave more like a diffuse than nodular lymphoma, and warrants appropriate therapy.

publication date

  • January 1977



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197709)40:3<1229::AID-CNCR2820400337>3.0.CO;2-F

PubMed ID

  • 332322

Additional Document Info

start page

  • 1229

end page

  • 33


  • 40


  • 3