Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor Academic Article uri icon


MeSH Major

  • Bone Marrow Transplantation
  • HLA Antigens
  • Immunologic Deficiency Syndromes


  • A patient with severe combined immunodeficiency received seven transplants of bone marrow from an HLA-B-compatible and HLA-D-compatible unrelated donor in an attempt to provide immunologic reconstitution. The first four transplants achieved restricted engraftment with evidence of rudimentary immunologic function. A fifth transplant, given after low-dose cyclophosphamide, produced reconstituion of cell-mediated immunity. Marrow aplasia developed after recontamination with a nonpathogenic microflora. Transplantation of marrow previously stored in liquid nitrogen was ineffective. A subsequent transplant, administered after high-dose cyclophosphamide, achieved durable engraftment, with complete hematopoietic and immunologic reconstitution. Seventeen months after transplantation, full functional engraftment persists. Graft-versus-host disease has been chronic and moderately severe, but limited to the skin and oral mucosa. Transplantation of marrow from unrelated histocompatible donors may provide a useful treatment for patients with severe combined immunodeficiency or aplastic anemia who lack a matched sibling or related donor.

publication date

  • December 1977



  • Academic Article



  • eng

PubMed ID

  • 21351

Additional Document Info

start page

  • 1311

end page

  • 8


  • 297


  • 24