Multifocal leukoencephalopathy in adult leukemia: Histologic features and etiologic considerations Academic Article Article uri icon

Overview

MeSH Major

  • Medical Tourism
  • Population Health

abstract

  • A number of structural alteration in brains of leukemic children have been attributed to intrathecal administration of methotrexate and radiation therapy. We report an instance of asymptomatic encephalopathy in an adult who received thio-TEPA (by subarachnoid injection) as treatment for leukemic meningitis. The lesions were microscopic, confined to cerebral white matter and included: vacuolation, myelin destruction, axonal swelling, gliosis, deposition of mineral salts and aggregates of large foamy cells. The etiology of this condition remains undetermined.

publication date

  • January 1977

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1007/BF00691966

PubMed ID

  • 414509

Additional Document Info

start page

  • 273

end page

  • 6

volume

  • 40

number

  • 3