CIRCULATING THYMIC-HORMONE ACTIVITY IN CONGENITAL IMMUNODEFICIENCY Academic Article Article uri icon

Overview

MeSH Major

  • Hematopoietic Stem Cell Transplantation
  • T-Lymphocytes
  • Thrombocytopenia

abstract

  • Circulating thymic-hormone activity was assayed by measuring Thy 1-2 antigen induction on null lymphocytes from athymic mice incubated with human plasma or serum. Plasma from 19 normal children aged under 10 had inductive activity equivalent to 10-6-16-2 ng thymopoitin/ml. Plasma from 15 infants were severe combined immuno-deficiency, 2 of whom had appreciable immunoglobulin synthesis, and from 2 infants with DiGeorge syndrome had little or no inductive activity. Successful reconstitution with thymus or bone-marrow grafts and with red-cell infusions (if adenosine-deaminase deficiency is present) was followed by a rise in circulating thymic-hormone activity.

publication date

  • September 3, 1977

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(77)91601-4

PubMed ID

  • 70687

Additional Document Info

start page

  • 471

end page

  • 5

volume

  • 310

number

  • 8036