Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. Academic Article uri icon

Overview

MeSH Major

  • Adenylyl Cyclases
  • Brain
  • Histamine H2 Antagonists
  • Lysergic Acid Diethylamide
  • Receptors, Histamine

abstract

  • D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the histamine H2-receptor. Both D-lysergic acid diethylamide and D-2-bromolysergic acid diethylamide show topological congruency with potent H2-antagonists. D-2-Bromolysergic acid diethylamide is 10 times more potent as an H2-antagonist than cimetidine, which has been the most potent H2-antagonist reported, and D-lysergic acid diethylamide is about equipotent to cimetidine. Blockade of H2-receptors could contribute to the behavioral effects of D-2-bromolysergic acid diethylamide and D-lysergic acid diethylamide.

publication date

  • December 1977

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC431860

PubMed ID

  • 23536

Additional Document Info

start page

  • 5697

end page

  • 701

volume

  • 74

number

  • 12