Measurement of liver blood flow in the rat using an 85krypton clearance technique Academic Article uri icon

Overview

MeSH Major

  • Liver
  • Radioisotope Dilution Technique

abstract

  • A method for the measurement of liver blood flow (LBF) in rats has been developed by recording the clearance of 85Kr from the liver after injection of a solution of the gas into the portal vein. This technique provides a measure of tissue perfusion at a cellular level. The animal preparation was maintained in a stable haemodynamic and respiratory state for up to 4-3 h by careful fluid and anaesthetic control. Stability of the model was reflected by relative constancy of the LBF measured throughout the experiment in all of the animals studied. The mean LBF determined in six rats was 2-41+/-(s.d.) 0-50 ml/g/min.

publication date

  • December 1977

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2041145

PubMed ID

  • 326287

Additional Document Info

start page

  • 236

end page

  • 42

volume

  • 58

number

  • 3