Liver dysfunction in patients with hemophilia A, B, and von Willebrand's disease Academic Article uri icon

Overview

MeSH Major

  • Blood Transfusion
  • Hemophilia A
  • Hemophilia B
  • Liver Diseases
  • von Willebrand Diseases

abstract

  • Ninety-five patients with Hemophilia A, B and von Willebrand's disease followed over a three year period were evaluated for liver disease. Half of the patients were treated episodically and half received additional prophylactic treatment. Fifty-five per cent have significant transaminitis (elevated SGOT-SGPT), 42 per cent have biochemical evidence of chronic active liver disease and two per cent have subacute and active cirrhosis. There is an annual attack rate of Hepatitis B disease of 3.5 per cent and Hepatitis B antibody titres are present in 84 per cent. This asymptomatic liver disease requires close monitoring for clinical significance.

publication date

  • December 1977

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 302996

Additional Document Info

start page

  • 495

end page

  • 9

volume

  • 17

number

  • 5