Renal transplantation between HLA identical siblings. Comparison with transplants from HLA semi identical related donors Academic Article Article uri icon

Overview

MeSH Major

  • Lupus Erythematosus, Systemic
  • Nephritis
  • Renal Dialysis

abstract

  • We compared 26 HLA-A, B identical sibling kidney-transplant recipients followed for one to 10 years, with 104 HLA-A, B semi-identical kidney recipients from living, related donors to determine clinical differences. Graft-survival rates were significantly better in the HLA identical group at two years (85 per cent identical versus 53 per cent in semi-identical, P less than 0.005); patient-survival rates were high for both (96 per cent in identical and 87 per cent in semi-identical at two years, P less than 0.005). The incidence of complications was similar in HLA identical and semi-identical recipients. Nine of the 26 grafts in HLA identical recipients failed one week to eight years after transplantation. Rejection caused most of the graft failures. Recipients of HLA identical-sibling kidney transplants have a high patient and graft survival, but they also encounter many complications. Immunologic rejection occurs, even with negative mixed lymphocyte culture, suggesting the importance of donor determinants other than the HLAA, B and D other than the HLA-A, B and D.

publication date

  • December 1977

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 139567

Additional Document Info

start page

  • 1030

end page

  • 4

volume

  • 296

number

  • 18 1030-1034)