Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia Academic Article uri icon


MeSH Major

  • Hepatectomy
  • Liver
  • Portacaval Shunt, Surgical


  • Portacaval transposition diverts portal blood from the liver. It allows systemic venous blood to perfuse the portal bed. Body weight and liver weight have been followed before and after portacaval transposition and control procedures in rats, and the DNA activity ratio studied in the liver of rats after partial hepatectomy in protacavally transposed animals. The results suggest that the liver atrophy seen after portal diversion is a result of diversion of trophic substances in the portal blood rather than of a decrease in absolute liver flow. Recovery of liver weight after partial hepatectomy in portacavally transposed animals occurs within the same time as in control animals, and the time course and magnitude of regenerative hyperplasia, as assessed by liver DNA activity ratio, is unimpaired.

publication date

  • December 1977



  • Academic Article



  • eng

PubMed Central ID

  • PMC2041272

PubMed ID

  • 861164

Additional Document Info

start page

  • 140

end page

  • 6


  • 58


  • 2