Granulocyte collagenase: selective digestion of type I relative to type III collagen Academic Article uri icon

Overview

MeSH Major

  • Fibroblasts
  • Macrophages
  • Microbial Collagenase
  • Neutrophils

abstract

  • Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

publication date

  • January 1977

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC430521

PubMed ID

  • 191839

Additional Document Info

start page

  • 897

end page

  • 901

volume

  • 74

number

  • 3