Combination antibiotic therapy in staphylococcal endocarditis. The use of methicillin sodium gentamicin sulfate therapy Academic Article Article uri icon

Overview

MeSH Major

  • Amphotericin B
  • Antiprotozoal Agents
  • Leishmaniasis, Visceral

abstract

  • The addition of gentamicin therapy in a case of S aureua endocarditis, in which the response to methicillin therapy alone was unsatisfactory, resulted in clinical improvement, enhanced serum bactericidal activity, and a bacteriologic cure. Gentamicin and methicillin were synergistic in vitro. Since the mortality in staphlococcal endocarditis remains exceedingly high, we suggest that the combination of a cell wall active antibiotic, such as methicillin, and an aminoglycoside may prove to be effective alternate theraphy for this disease.

publication date

  • December 1976

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1001/archinte.136.4.480

PubMed ID

  • 1267557

Additional Document Info

start page

  • 480

end page

  • 3

volume

  • 136

number

  • 4