Collagenase from rabbit pulmonary alveolar macrophages Academic Article Article uri icon


MeSH Major

  • Braces
  • Exercise Therapy
  • Intervertebral Disc
  • Low Back Pain
  • Spinal Diseases


  • Rabbit pulmonary alveolar macrophages produce a collagenase which lyses labeled collagen gels, specifically cleaves collagen types I, II and III, is inhibited by ethylenediaminetetraacetate, cysteine, dithiothreitol and serum but is not inhibited by a serine protease inhibitor. Alveolar macrophage collagenase activity can be enhanced by in vivo BCG activation, in vitro latex, silica or mycobacterium activation and by in vitro uncovering of latent enzymatic activity with trypsin treatment. The production of collagenase by unactivated alveolar macrophages and the presence of "latent" collagenase in culture media of alveolar macrophages are examples of significant differences between alveolar and peritoneal macrophages. © 1976.

publication date

  • March 22, 1976



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(76)90521-0

PubMed ID

  • 178308

Additional Document Info

start page

  • 296

end page

  • 303


  • 69


  • 2