Inhibition of chemical induction of porphyrin synthesis in chick embryo liver cells by partially purified human chorionic gonadotropin Academic Article Article uri icon


MeSH Major

  • Antidepressive Agents
  • Anxiety Disorders
  • Cycloserine
  • Excitatory Amino Acid Agonists
  • Implosive Therapy
  • N-Methylaspartate
  • Obsessive-Compulsive Disorder
  • Outcome Assessment (Health Care)
  • Stress Disorders, Post-Traumatic


  • Commercial preparations of human chorionic gonadotropin (hCG) inhibited chemical induction of δ -aminolevulinic acid synthetase and porphyrin formation in chick embryo liver cell cultures. The inhibition was not attributable to hCG since highly purified preparations of the hormone were not inhibitory. After fractionation of crude hCG on Sephadex G-100, inhibitory activity was found in two fractions, one of slightly smaller and one of much smaller molecular weight than hCG. Thus partially purified hCG may have other biologic effects than those caused by the hormone itself. Moreover, the occurrence of substances in crude hCG which at low concentrations can interfere with drug and hormone effects on liver cells is of biologic and potential clinical interest. © 1976.

publication date

  • January 26, 1976



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(76)91174-8

PubMed ID

  • 943165

Additional Document Info

start page

  • 503

end page

  • 10


  • 68


  • 2