A clinical study of the lupus anticoagulant Academic Article uri icon

Overview

MeSH Major

  • Anticoagulants
  • Lupus Erythematosus, Systemic

abstract

  • Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus anticoagulant was augmented in 67% of these patients by a cofactor present in normal plasma. The lupus inhibitor was detected primarily because of an unsuspected abnormal coagulation test. One-half of the patients with the lupus-type anticoagulant did not have systemic lupus erythematosus.

publication date

  • December 1976

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 963290

Additional Document Info

start page

  • 499

end page

  • 509

volume

  • 48

number

  • 4