Long term survival of skin allografts in mice treated with fractionated total lymphoid irradiation Academic Article uri icon

Overview

MeSH Major

  • Graft Rejection
  • Lymphoid Tissue
  • Radiation Effects

abstract

  • Treatment of recipient Balb/c mice with fractionated, high-dose total lymphoid irradiation, a procedure commonly used in the therapy of human malignant lymphomas, resulted in fivefold prolongation of the survival of C57BL/Ka skin allografts despite major histocompatibility differences between the strains (H-2d and H-2b, respectively). Infusion of 10(7) (C57BL/Ka x Balb/c)F1 bone marrow cells after total lymphoid irradiation further prolonged C57BL/Ka skin graft survival to more than 120 days. Total lymphoid irradiation may eventually prove useful in clinical organ transplantation.

publication date

  • December 1976

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 785599

Additional Document Info

start page

  • 1252

end page

  • 4

volume

  • 193

number

  • 4259