USE OF COAGULATION TESTS TO PREDICT THE CLINICAL PROGRESS OF PRE-ECLAMPSIA Academic Article Article uri icon

Overview

MeSH Major

  • Melanoma
  • Proto-Oncogene Proteins B-raf
  • Receptor, Melanocortin, Type 1
  • Skin Neoplasms

abstract

  • The clinical manifestations of severe pre-eclampsia are normally separated from those of mild pre-eclampsia and normal pregnancy on arbitrary grounds. A clinical index, based on the increase in diastolic blood-pressure and the presence of proteinuria, was developed to reflect the spectrum of disease from mild to severe pre-eclampsia. This was related to a coagulation index based on the platelet-count, plasma-factor-VIII, and serum-fibrinolytic-degradation-products. The two indices were shown to be strongly correlated. All cases of perinatal death associated with pre-eclampsia had coagulation indices in the most severely abnormal range. These results suggest that intravascular coagulation is a highly characteristic feature of pre-eclampsia and that the coagulation index may be of value in monitoring the progress of the disease.

publication date

  • August 14, 1976

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(76)92587-3

PubMed ID

  • 60564

Additional Document Info

start page

  • 323

end page

  • 5

volume

  • 308

number

  • 7981