Glanzmann's Thrombasthenia; Assessment of the Response to Platelet Transfusions Academic Article Article uri icon


MeSH Major

  • Abortifacient Agents, Nonsteroidal
  • Misoprostol


  • The response to platelet transfusions was studies in two patients with Glanzmann's thrombasthenia. Antibodies to platelets were detected in one patient who had failed to respond to platelet transfusions, and bled during and after surgery despite fresh whole blood transfusions. The other patient had no detectable antiplatelet antibodies, exhibited improved platelet function when normal platelets were added to her platelet-rich plasma and experienced a favorable response to platelet transfusions during major surgery. These cases demonstrate the importance of antiplatelet antibodies as a determinant of a patient's response to platelet transfusion, the value of this therapy in qualitative platelet disorders, and the potential usefulness of in vitro studies to predict the outcome of platelet transfusions in such patients.

publication date

  • January 1975



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1046/j.1537-2995.1975.15275122805.x

PubMed ID

  • 1167989

Additional Document Info

start page

  • 124

end page

  • 31


  • 15


  • 2