Subcellular platelet factor VIII antigen and von Willebrand factor Academic Article uri icon

Overview

MeSH Major

  • Antigens
  • Blood Platelets
  • Cell Membrane
  • Cytoplasmic Granules
  • Factor VIII

abstract

  • Subcellular membrane and granule fractions derived from human platelets contain factor VIIII antigen and von Willebrand factor activity but not factor VII procoagulant activity. Circulating platelets constitute a significant reservoir of plasma factor VIII antigen, containing approximately 15% of the amount of factor VIII antigen present in platelet-poor plasma. The antibiotic ristocetin, which aggregates human platelets in the presence of von Willebrand factor, nonspecifically precipitates platelet membrane factor VIII antigen. Thus normal platelets contain surface-bound as well as internally stored von Willebrand factor, a protein synthesized by endothelial cells which is necessary for normal platelet function in vivo.

publication date

  • December 1975

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2189790

PubMed ID

  • 1168691

Additional Document Info

start page

  • 1101

end page

  • 13

volume

  • 141

number

  • 5