Phenytoin and Membrane Fluidity in Myotonic Dystrophy Academic Article Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • Ureteral Neoplasms
  • Ureteral Obstruction

abstract

  • Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) "normalizes" fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.

publication date

  • January 1975

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1001/archneur.1975.00490500055006

PubMed ID

  • 168843

Additional Document Info

start page

  • 535

end page

  • 8

volume

  • 32

number

  • 8