Accumulation of 5-oxo-l-proline and 5-oxo-d-proline in the blood plasma in end stage renal disease
Phospholipid Transfer Proteins
To learn more about the metabolic and clinical significance of 5-oxoproline (pyroglutamate, pyrrolidone carboxylate), we investigated the blood plasma concentrations of 5-oxo-l-proline and 5-oxo-d-proline in normal individuals and in patients with renal failure. Normal plasma levels of total 5-oxoproline of 7-19 μm (mean, 13.9 ± 4 μm) were found; about 10% of the total 5-oxoproline is of the d-configuration. Patients with renal failure had plasma levels of 5-oxo-l-proline that were about 3.5 times higher than normal, and 5-oxo-d-proline levels that were about 25 times higher than the normals. No significant differences were found between the results obtained on anephric patients and those on the other patients with renal failure. The findings, which are relevant to the role of the kidney in glutathione and amino acid metabolism, reflect the significant function of the kidney in the utilization of 5-oxo-l-proline by 5-oxo-l-prolinase and in the excretion of 5-oxo-d-proline. © 1975.
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