γ-Glutamyl transpeptidase of rat seminal vesicles; Effect of orchidectomy and hormone administration on the transpeptidase in relation to its possible role in secretory activity Academic Article uri icon

Overview

MeSH Major

  • Phospholipid Transfer Proteins

abstract

  • γ-Glutamyl transpeptidase was prepared from rat seminal vesicles by two methods and was found to be similar to rat kidney γ-glutamyl transpeptidase with respect to substrate specificity, stimulation of "glutaminase" activity by maleate, and apparent molecular weight. Histochemical studies demonstrated that γ-glutamyl transpeptidase is concentrated in the secretory epithelium of the seminal vesicle. Like the epithelium itself, the enzyme responds to the presence or absence of testosterone. The content and specific activities of γ-glutamyl transpeptidase and γ-glutamyl cyclotransferase in rat seminal vesicles are low in orchidectomized animals, an effect which is reversed by administration of testosterone but accentuated by estradiol administration. These enzymes may be involved in the secretory functions of the seminal vesicles. © 1975.

publication date

  • March 1975

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(75)90346-X

Additional Document Info

start page

  • 691

end page

  • 704

volume

  • 16

number

  • 5