Dopamine β hydroxylase activity in brains of chronic schizophrenic patients Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Dopamine beta-Hydroxylase
  • Schizophrenia

abstract

  • Postmorten brain specimens from nine chronic schizophrenic patients and nine control were assayed for activity of dopamine beta-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine. Unlike the results of previous reports, there was no statistically significant difference in enzyme activity between the patient and control groups. There were, however, significant negative correlations between dopamin beta-hydroxylase activity and the tim spent in the morgue before autopsy, and between enzyme activity of schizophrenics and dosage of chlorpromazine or its equivalent.

publication date

  • January 1975

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 1111112

Additional Document Info

start page

  • 368

end page

  • 70

volume

  • 187

number

  • 4174