Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats
Saccharomyces cerevisiae Proteins
After rats were injected with the convulsant methionine sulfoximine, there was a rapid decrease in the glutathione concentrations of the kidney and liver, but there was no measurable effect (within 5 hours) on brain glutathione. The maximum decreases in the glutathione concentrations of kidney and liver were observed 1 hr after injection and were about 60 and 40%, respectively, of the control levels. The findings suggest that there may be at least two pools of tissue glutathione. Studies in which other amino acids were injected, and earlier in vitro studies, are consistent with the conclusion that methionine sulfoximine affects glutathione synthesis in vivo by inhibiting γ-glutamylcysteine synthetase. Injection of glycylglycine also decreased glutathione levels, an effect probably mediated by γ-glutamyltranspeptidase. © 1975.
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