Teratogenic effects of trimethadione and dimethadione in the chick embryo Academic Article Article uri icon


MeSH Major

  • Antidepressive Agents
  • Anxiety Disorders
  • Cycloserine
  • Excitatory Amino Acid Agonists
  • Implosive Therapy
  • N-Methylaspartate
  • Obsessive-Compulsive Disorder
  • Outcome Assessment (Health Care)
  • Stress Disorders, Post-Traumatic


  • Several anticonvulsants including the oxazolidinediones, trimethadione, and paramethadione have been implicated as possible human teratogens. In the studies reported here, both trimethadione in doses of 10-20 mg/egg and its metabolite, dimethadione, in doses of 10-30 mg/egg were shown to be teratogenic when injected into chick embryos during early development. Trimethadione produced a variety of malformations. It was shown to have a teratogenic impact prior to the time the embryo was capable of metabolizing it to dimethadione. The principal abnormality produced by dimethadione was celosomia. © 1974.

publication date

  • January 1974



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0041-008X(74)90266-X

PubMed ID

  • 4446037

Additional Document Info

start page

  • 452

end page

  • 7


  • 30


  • 3