Teratogenic effects of trimethadione and dimethadione in the chick embryo
Excitatory Amino Acid Agonists
Outcome Assessment (Health Care)
Stress Disorders, Post-Traumatic
Several anticonvulsants including the oxazolidinediones, trimethadione, and paramethadione have been implicated as possible human teratogens. In the studies reported here, both trimethadione in doses of 10-20 mg/egg and its metabolite, dimethadione, in doses of 10-30 mg/egg were shown to be teratogenic when injected into chick embryos during early development. Trimethadione produced a variety of malformations. It was shown to have a teratogenic impact prior to the time the embryo was capable of metabolizing it to dimethadione. The principal abnormality produced by dimethadione was celosomia. © 1974.
Digital Object Identifier (DOI)
Additional Document Info
has global citation frequency