Effects of maleylation on the lipid-binding and immunochemical properties of human plasma high density apolipoprotein-A-II Academic Article Article uri icon


MeSH Major

  • Obesity
  • Thinness
  • Weight Gain


  • Chemical modification by maleylation of the human plasma high density lipoprotein-protein, apoA-II, causes significant changes in its properties. These changes are as follows: 1) a shift from a helical to a more disordered secondary structure; 2) a decreased ability to bind egg phosphatidylcholine vesicles; and 3) a decrease in immunoreactivity as measured by a quantitative radioimmunoassay. Each of these changes was reversed by demaleylation. These results are discussed in relation to a molecular theory of lipid binding by the plasma lipoproteins. © 1974 Academic Press, Inc.

publication date

  • December 23, 1974



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0006-291X(74)80428-6

PubMed ID

  • 4376009

Additional Document Info

start page

  • 1317

end page

  • 24


  • 61


  • 4