Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors Academic Article uri icon

Overview

MeSH Major

  • Bungarotoxins
  • Myasthenia Gravis
  • Neuromuscular Junction
  • Receptors, Cholinergic
  • Serum Globulins

abstract

  • Serum factors that inhibit the binding of (125)I-labeled alpha-bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.

publication date

  • December 1974

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 4421998

Additional Document Info

start page

  • 55

end page

  • 7

volume

  • 186

number

  • 4158