Assessment of liver regeneration in the rat using the gamma camera
A method of imaging the liver of the rat using a pinhole collimator and a gamma camera is described. The method allows imaging of other organs in small animals. Radioisotopic scintigraphs of the rat liver using 99Tc(m) sulfur colloid and 75Se L selenomethionine have been obtained before and at intervals after partial hepatectomy. The sizes of the scintigraphs of the two compounds were closely similar and there was no obvious difference in their distribution within the liver, either before or at any time after partial hepatectomy. A close correlation was found between the mean area of the lateral scintigraphs of the liver and liver weight (r = 0.95), and a formula was derived whereby liver weight could be calculated from the size of the scintigraphs. Following two thirds partial hepatectomy in the rat the remnant was found to regain its normal mass within 7-10 days. The results support the use of technetium sulfur colloid in the clinical assessment of liver regeneration after hepatectomy.