Cell cycle changes in ovarian cancer after arabinosylcytosine Academic Article Article uri icon

Overview

MeSH Major

  • Cardiovascular Diseases
  • Genetic Variation
  • Indians, North American
  • Mannose-Binding Lectin

abstract

  • Cytokinetic studies were performed using 3H‐thymidine and autoradiographic methods before and after arabinosylcytosine in a patient with ascites due to recurrent ovarian carcinoma. Before Ara‐C, the ascitic fluid had 1900 tumor cells/mm3 the ascitic glucose level was 10 mg%, while after Ara‐C the ascitic tumor cell count was 32/mm3 the ascitic glucose level was 60 mg%. The mean generation time (TG) was calculated from the median grain count halving time, and the durations of the phases of the cell cycle from the labeled mitoses curves. Before chemotherapy, the flash labeling index (L.I.) was 14%; the mitotic index (M.I.) was 0.4%; TG = : 180 hrs (total labeled population) and 99 hrs (rapidly proliferating component); S = 62 hrs; G2 = 6.6 hrs; M = 2.4 hrs; and G1 = 28 hrs. After Ara‐C the flash L.I. was 40%; M.I. = 1.5%; TG = 73 hrs (total labeled population) and 45 hrs (rapidly proliferating component); S = 34 hrs; G2 = 7.0 hrs; M = 1.0 hr; and G1 = 3 hrs. In this ascitic tumor, when chemotherapy reduced the cell concentration, the remaining viable cells grew more rapidly than the unperturbed cells. The question of whether this phenomenon may have been due to a lowered cell density, increased nutrient supply, or to changes in growth regulatory substances is discussed. Copyright © 1974 American Cancer Society

publication date

  • January 1974

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197401)33:1<28::AID-CNCR2820330108>3.0.CO;2-L

PubMed ID

  • 4810102

Additional Document Info

start page

  • 28

end page

  • 37

volume

  • 33

number

  • 1