Porphyrin heme pathway: Regulation by intermediates in bile acid synthesis Academic Article uri icon

Overview

MeSH Major

  • 5-Aminolevulinate Synthetase
  • Cholestanes
  • Liver
  • Porphyrins

abstract

  • Dihydroxycoprostane and trihydroxycoprostane, intermediates in normal bile acid synthesis in the liver, enhanced the rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinate synthetase, the rate-limiting enzyme for this pathway. Other 5beta-cholestane derivatives and cholest-5-ene derivatives were ineffective. The selectivity of the induction may indicate that the above-mentioned coprostanes have a physiological role in porphyrin synthesis.

publication date

  • December 1973

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 4795750

Additional Document Info

start page

  • 841

end page

  • 2

volume

  • 182

number

  • 4114