The vision of intravenous nourishment — as ancient as the hollow needle and the venipuncture — was given substance by sterile solutions of glucose in water at the time of World War I. By the late 1930's intravenous protein hydrolysates were under study,1 and within 10 years appeared the first reports of a fat emulsion for intravenous use.2 By 1950, it was evident that synthetic requirements for protein anabolism included the simultaneous administration of an adequate caloric substrate to inhibit the utilization of the administered amino acids for gluconeogenesis, and to cover the energy needs of peptide bond formation.3 Five. © 1972, Massachusetts Medical Society. All rights reserved.
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