Genetic variation in activity of enzymes involved in synthesis of catecholamines. Academic Article uri icon

Overview

MeSH Major

  • Adrenal Glands
  • Brain
  • Genes
  • Genetic Variation
  • Methyltransferases
  • Mixed Function Oxygenases
  • Tyrosine 3-Monooxygenase

abstract

  • A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carried by the CBA/J strain appeared to be dominant to those of the other strains. The pattern of inheritance of tyrosine hydroxylase activity in adrenals differed from that in the brain. In both tissues, dominant genes appeared to determine intermediate, rather than extreme, levels of enzyme activities.

publication date

  • September 1972

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC426962

PubMed ID

  • 4403563

Additional Document Info

start page

  • 2448

end page

  • 50

volume

  • 69

number

  • 9