Chondroblastoma of bone. A clinicopathologic and electron microscopic study Academic Article Article uri icon

Overview

MeSH Major

  • DNA Methylation
  • Exons
  • Gene Silencing
  • Transcription, Genetic

abstract

  • Twenty‐five patients with benign chondroblastoma of bone were treated at Memorial Sloan‐Kettering Cancer Center, from 1920 to 1970. The 15 male and 10 female patients, with an age range of 9 to 51 years, were treated by amputation, block excision, curettage, cryosurgery, and irradiation. The follow‐up period ranged up to 35 years with extremely slow gradual healing as demonstrated by sequential roentgenograms. No malignant transformation had occurred; however, one case exhibited soft tissue implantation. The lesion was characterized by a high recurrence rate of 38%. In 24% of all cases, aneurysmal bone cyst was engrafted on the tumor, resulting in a significantly higher recurrence rate. In 2 cases, electron microscopic examination revealed multiple small Golgi complexes, numerous electron‐lucent mitochondria, dilated segments of rough endoplasmic reticulum, and small bundles of cytoplasmic filaments, in the cytoplasm of the tumor cells. Patches of glycogen were also seen in some of the chondroblasts. The nuclei were irregularly shaped, and some were also multilobulated. A fibrous lamina was closely applied to the inner surface of the nuclear envelope of the chondroblasts. Copyright © 1972 American Cancer Society

publication date

  • January 1972

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197203)29:3<760::AID-CNCR2820290332>3.0.CO;2-U

PubMed ID

  • 5060653

Additional Document Info

start page

  • 760

end page

  • 71

volume

  • 29

number

  • 3