Cyclic chemotherapy in lymphoma Academic Article Article uri icon


MeSH Major

  • Heart Ventricles
  • Purkinje Fibers
  • Signal Processing, Computer-Assisted


  • This study evaluates the cyclic use of a combination of four drugs—cyclophosphamide, vincristine, procarbazine, and prednisone in 12 patients with generalized lymphosarcoma (LSA) and 11 patients with reticulum cell sarcoma (RCS). Seven patients with LSA achieved a category I response, and of these, 4 are clinically free of disease. In the RCS group, only one achieved a category I response. Myelosuppression was severe in 4 patients (17%) and may have contributed to their deaths from infectious complication. A high incidence of extranodal involvement in this group of patients appeared to correlate with the low incidence of useful therapeutic responses. Copyright © 1971 American Cancer Society

publication date

  • January 1971



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(1971)28:4<886::AID-CNCR2820280411>3.0.CO;2-G

PubMed ID

  • 4939250

Additional Document Info

start page

  • 886

end page

  • 93


  • 28


  • 4