ASSOCIATION BETWEEN POLYARTERITIS AND AUSTRALIA ANTIGEN Academic Article Article uri icon

Overview

MeSH Major

  • Antibodies, Antiphospholipid
  • Anticoagulants
  • Antiphospholipid Syndrome
  • Warfarin

abstract

  • Four of eleven patients with biopsyproven polyarteritis nodosa were also found to have Australia (Au) antigenæmia. The four Au-antigen-positive patients exhibited a typical polyarteritis syndrome, but differed from the seven antigen-negative patients in that they also had evidence of mild hepatic damage. The presence of circulating immune complexes in the sera of three of the four Au-antigen-positive patients was demonstrated by serological, ultracentrifugal, and electro-microscopic studies. These complexes were further shown to be composed of Au antigen and immunoglobulin. Immunofluorescent studies of tissue from one of the patients revealed deposition of Au antigen, IgM, and β1C in blood-vessel walls. © 1970.

publication date

  • December 5, 1970

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(70)90339-9

PubMed ID

  • 4098431

Additional Document Info

start page

  • 1149

end page

  • 53

volume

  • 296

number

  • 7684