ASSOCIATION BETWEEN POLYARTERITIS AND AUSTRALIA ANTIGEN
Four of eleven patients with biopsyproven polyarteritis nodosa were also found to have Australia (Au) antigenæmia. The four Au-antigen-positive patients exhibited a typical polyarteritis syndrome, but differed from the seven antigen-negative patients in that they also had evidence of mild hepatic damage. The presence of circulating immune complexes in the sera of three of the four Au-antigen-positive patients was demonstrated by serological, ultracentrifugal, and electro-microscopic studies. These complexes were further shown to be composed of Au antigen and immunoglobulin. Immunofluorescent studies of tissue from one of the patients revealed deposition of Au antigen, IgM, and β1C in blood-vessel walls. © 1970.
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