Toxicity of E. coli L‐asparaginase in man Academic Article Article uri icon


MeSH Major

  • Cardiovascular Diseases
  • Genetic Variation
  • Indians, North American
  • Mannose-Binding Lectin


  • During therapeutic trials with E. coli L‐asparaginase in 131 children and 143 adults with neoplastic disease the following signs of toxicity have been observed: fever, nausea and vomiting, weight loss, somnolence, lethargy, confusion, hypolipidemia, hyperlipidemia, hypoproteinemia, abnormal liver function tests, fatty metamorphosis of the liver, pancreatitis (in rare instances), azotemia, granulocytopenia, lymphopenia, thrombocytopenia, and hypersensitivity reactions. While these effects have been moderately severe and reversible in most instances, some patients have shown dangerous degrees of toxicity. This has been the case most frequently in adult patients receiving a dose of 5000 IU/kg/day. Copyright © 1970 American Cancer Society

publication date

  • January 1970



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197002)25:2<253::AID-CNCR2820250204>3.0.CO;2-U

PubMed ID

  • 4905153

Additional Document Info

start page

  • 253

end page

  • 78


  • 25


  • 2