Electron microscopic study of human leukemic cells in tissue culture Academic Article Article uri icon


MeSH Major

  • Cardiovascular Diseases
  • Genetic Variation
  • Indians, North American
  • Mannose-Binding Lectin


  • Cell lines originating from three cases of acute human leukemia have been studied under the electron microscope. The fine structure of the cultured cells has been compared to that of the patients' circulating leukocytes and progressive dedifferentiation has been described. After several months in culture, most of the cells resemble large primitive blasts or stem cells. One line, however, showed a transient wave of differentiation with the appearance of eosinophilic metamyelocytes. Problems of myeloid‐cell nomenclature have been raised in the light of the study of the same material by conventional hematologic methods. Virus particles were not observed in the patients' circulating leukocytes, or in the cell cultures derived from them, despite repeated efforts to induce some degree of cell degeneration. Copyright © 1967 American Cancer Society

publication date

  • January 1967



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(196706)20:6<911::AID-CNCR2820200602>3.0.CO;2-N

PubMed ID

  • 5229524

Additional Document Info

start page

  • 911

end page

  • 25


  • 20


  • 6