Selective ablation of atheromas using a flashlamp-excited dye laser at 465 nm Academic Article Article uri icon

Overview

MeSH Major

  • Algorithms
  • Heart Ventricles
  • Hypertrophy, Left Ventricular
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Ventricular Remodeling

abstract

  • Ablation of human atheromas with laser pulses that had only a small effect on normal artery tissue was shown in vitro in air and under saline using 1-mu sec pulses at 465 nm from a flashlamp-excited dye laser. At this wavelength, there is preferential absorption in atheromas due to carotenoids. The threshold fluence for ablation was 6.8 +/- 2.0 J/cm2 for atheromas and 15.9 +/- 2.2 J/cm2 for normal aorta tissue. At a fluence of 18 J/cm2 per pulse, the ablated mass per unit of energy ranged from 161 to 370 micrograms/J for atheromas and from 50 to 74 micrograms/J for normal aorta tissue. Ablation products consisted of cholesterol crystals, shredded collagen fibers, and small bits of calcific material. Most debris was less than 100 micron in diameter, but a few pieces were as large as 300 micron. High-speed photography of ablation in air suggested explosive ejection of debris, caused by vapor formation, at speeds on the scale of 300 m/sec. Histological analysis showed minimal thermal damage to residual tissue. These data indicate that selective laser ablation of atheromas is possible in vitro.

publication date

  • December 19, 1986

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.83.18.7064

PubMed ID

  • 3462744

Additional Document Info

start page

  • 7064

end page

  • 8

volume

  • 83

number

  • 18